Senior / Principal Scientist, Medicinal Chemistry

Location: San Francisco Bay Area, CA; salary ranges are specified for Redwood City, CA.

Salary: $174,800–$224,100 for Senior Scientist I; $215,200–$275,900 for Senior Scientist II; $246,600–$316,100 for Principal Scientist I.

Company

hirify.global is a biotechnology company developing cell rejuvenation approaches to restore cell health and resilience and address disease, injury, and age-related disability.

What you will do

• Advance one or more small-molecule drug discovery programs from hit identification through lead optimization and candidate selection.
• Design drug-like molecules and synthesize novel compounds using structure-based, computational, and property-based methods.
• Perform multi-step synthesis, retrosynthetic analysis, purification, characterization, and troubleshooting with internal laboratories and CRO partners.
• Analyze and communicate structure-activity relationship data to guide compound design and program direction.
• Design compounds addressing potency, physical-property, and ADMET challenges.
• Collaborate with Drug Metabolism and Pharmacokinetics, Structural Biology, pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease-area Biology functions; present findings to internal and external stakeholders.

Requirements

• Ph.D. in Organic Chemistry with 6+ years of post-Ph.D. experience, or equivalent and relevant chemical research experience.
• Experience preferably in a biotechnology or pharmaceutical setting.
• Proven expertise in modern synthetic organic chemistry, supported by a strong record of lead-author publications and/or patents.
• Understanding of medicinal chemistry principles and experience across hit identification, hit-to-lead, and lead optimization.
• Experience with structure-based drug design.
• Contemporary expertise in organic chemistry, including modern synthetic methodologies, multi-step route design, compound purification, and characterization.
• Strong verbal and written communication skills and the ability to deliver effective presentations.
• Highly collaborative, team-oriented, considerate, and results-oriented approach.

Culture & Benefits

• Collaborative, fast-paced environment focused on scientific excellence, learning, belonging, and inclusive teamwork.
• Opportunity to contribute to life-changing medicines addressing unmet patient needs.
• Potential to lead chemistry programs and manage external CRO chemistry FTEs.
• Equal employment opportunities are provided without regard to protected characteristics under applicable law.

Hiring process

• UK applicants must read the hirify.global EU and UK Applicant Privacy Notice before submitting an application.