Data Science Fellow — Organoid Biochemistry

Location: Bethesda, MD, United States

Salary: $90,000–$100,000 USD base compensation per year

Company

hirify.global is a bioscience and information technology company developing translational research, biomedical informatics, and data science tools for research centers and healthcare organizations.

What you will do

• Establish molecular biology, recombinant protein expression, purification, conjugation, and biochemical-assay support for organoid projects.
• Implement APB-Display, APB-SortSeq, and APB-TiteSeq for protein and nanobody library production, screening, and quantitative binding measurements.
• Design focused nanobody and affinity-reagent libraries informed by computational design, biological targets, toxicity hypotheses, and imaging or spectroscopy needs.
• Establish SMA/SMALP and related membrane-active-polymer workflows to extract membrane proteins and preserve native protein-lipid assemblies.
• Validate binders and interactions using orthogonal assays, and apply quality-control methods to native nanodiscs and membrane complexes.
• Create SOPs, reagent inventories, assay criteria, metadata, and training modules while collaborating with imaging, spectroscopy, toxicology, computational, and core-facility teams.

Requirements

• PhD in biochemistry, molecular biology, chemical biology, protein chemistry, biophysics, bioengineering, cell biology, or a closely related field.
• Hands-on experience with recombinant protein expression and purification, molecular cloning, quantitative binding assays, or protein-interaction analysis.
• Strong understanding of protein structure-function relationships, membrane biology, assay controls, and quantitative experimental design.
• Ability to work with mammalian cells or complex biological samples and collaborate with imaging, spectroscopy, toxicology, computational, and core-facility teams.
• Ability to rigorously document methods, analyze data using Python, R, MATLAB, or comparable tools, and communicate results through reports, presentations, and manuscripts.

Nice to have

• Experience with nanobodies, antibody engineering, display technologies, pooled libraries, FACS, next-generation sequencing, cell-free protein synthesis, microfluidics, or hydrogel beads.
• Experience with styrene-maleic-acid polymers, SMALPs, native nanodiscs, membrane-protein purification, lipidomics, quantitative proteomics, mass spectrometry, or electron microscopy sample preparation.
• Experience with organoids, stem-cell-derived models, toxicology, chemical exposures, fluorescence imaging, or multi-omics integration.
• A strong record of method development, troubleshooting, collaborative publications, and independent experimental execution.

Culture & Benefits

• Medical, dental, and vision coverage for employees.
• Paid time off and paid holidays.
• 401(k) match up to 5%.
• Educational benefits for career growth and an employee referral bonus.
• Healthcare, parking, dependent-care, and transportation flexible spending accounts.
• Work with research organizations and facilities, including institutes at the National Institutes of Health.