Postdoctoral Associate (Rare Disease Genomics)

Location: On-site at the hirify.global in Cambridge, MA, United States.

Salary: $70,000–$92,666.67 per year.

Company

hirify.global is a biomedical research institute developing genomic and cellular approaches to understand disease and identify potential treatments.

What you will do

• Develop and optimize pooled optical screens linking disease-associated genetic variants with protein localization and high-dimensional cellular phenotypes.
• Refine multiplexed staining, fluorescence imaging, in situ sequencing, and related optical profiling workflows.
• Investigate promising variant phenotypes and compound responses through mechanistic studies in disease-relevant cell models, including iPSC-derived or primary human cells where appropriate.
• Lead primary compound screens, secondary dose-response experiments, validation, assay controls, and reproducibility efforts.
• Collaborate with computational biologists and disease-area experts to interpret imaging data, prioritize findings, and design follow-up experiments.
• Prepare manuscripts, present discoveries, contribute datasets and methods, and mentor junior researchers.

Requirements

• Ph.D. in molecular biology, cell biology, genetics, functional genomics, bioengineering, chemical biology, systems biology, or a related field.
• Strong hands-on experience in mammalian cell culture, molecular biology, and fluorescence microscopy.
• Demonstrated ability to independently design, troubleshoot, and interpret experiments and advance a research project, evidenced by first-author publications or preprints.
• Clear written and verbal communication, strong organizational skills, and a collaborative approach to research.

Nice to have

• Experience in mechanistic cell biology, human genetics, or research on Mendelian or rare diseases.
• Experience with genetic perturbation screens, barcoded library construction, lentiviral transduction, or cell line engineering.
• Experience with automated or high-content microscopy, compound screening, multiplexed immunostaining, in situ sequencing, or related optical profiling methods.
• Experience with disease-relevant cell models, including human iPSCs, differentiated lineages, or primary cells.
• Quantitative image analysis or scientific programming using tools such as CellProfiler, Fiji, Python, or R.

Culture & Benefits

• Emphasis on scientific independence, collaborative research, mentorship, and career development.
• Research training supports future leadership roles in academia or industry.
• Support and encouragement for applying for external fellowships.
• Benefits include medical, dental, vision, life, and disability insurance, a 401(k) plan, flexible spending and health savings accounts, paid holidays, winter closure, paid time off, parental and family care leave, and an employee assistance program.

Hiring process

• Submit a CV, contact information for three references, and a brief cover letter.
• Describe research interests, relevant experience, and one or two questions to pursue in the lab.
• Applications are reviewed on a rolling basis until the position is filled.