Computational Chemistry Research Scientist (Computational Drug Design)

Location: Boston, MA, United States. Hybrid arrangement allows remote work up to two days per week, or on-site work five days per week with ad hoc flexibility.

Base salary: $108,000–$162,000 per year, plus eligibility for annual bonus and equity awards.

Company

Vertex is a global biotechnology company focused on scientific innovation and the development of better outcomes for patients.

What you will do

• Apply computational chemistry methods to accelerate hit and lead identification, optimization, and drug candidate development.
• Collaborate with chemists, structural biologists, biologists, and research project scientists on interdisciplinary discovery programs.
• Use physics-based methods, generative models, and machine learning to design new chemical entities.
• Develop computational methodologies, workflows, and reusable methods with computational chemists and cheminformaticians.
• Expand computational chemistry capabilities and support global R&D collaborations across DMPK, Structural Biology, and Safety Assessment.
• Guide scientists and influence project teams through computational methods, data analysis, and timely decision-making.

Requirements

• Ph.D. or equivalent degree in Computational Chemistry.
• 0–3 years of productive, relevant employment experience in computational drug design.
• Strong expertise in structure-based drug design and current computational chemistry approaches for drug discovery.
• Experience with commercial and open-source molecular modeling software.
• Experience using modern AI computational capabilities for design and discovery workstreams.
• Strong programming, data analysis, communication, interpersonal, and presentation skills, including expertise in Python or similar scripting languages.

Culture & Benefits

• Continuous learning and exposure to advances in AI, technology, automation, and industry trends.
• Medical, dental, and vision benefits with paid time off and company shutdowns in summer and winter.
• Educational assistance programs, including student loan repayment.
• Commuting subsidy, matching charitable donations, and 401(k).
• Inclusive workplace with reasonable accommodations and equal employment opportunity.