7 дней назад
Scientist - LC-MS Bioanalytical
109 020 - 147 498$
Мэтч & Сопровод
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Описание вакансии
Текст:
TL;DR
Scientist - LC-MS Bioanalytical (Biotech): Developing and validating LC-MS/MS bioanalytical methods for small molecules, oligonucleotides, proteins, and other complex molecular entities with an accent on quantitative mass spectrometry, regulated bioanalysis, and automation. Focus on analyzing nonclinical and clinical matrices, improving assay throughput and sensitivity, and delivering compliant data and documentation for discovery and development programs.
Location: US - California - Thousand Oaks
Salary: $109,020.15–$147,497.85 annually
Company
is a biotechnology company developing, manufacturing, and delivering medicines for serious illnesses across oncology, inflammation, general medicine, and rare disease.
What you will do
- Design, develop, validate, and implement quantitative LC-MS/MS bioanalytical methods for small molecules, oligonucleotides, proteins, and other complex molecular entities.
- Plan, execute, document, analyze, and present bioanalytical experiments using nonclinical and clinical matrices including plasma, urine, cerebrospinal fluid, and tissues.
- Perform biological sample preparation using protein precipitation, solid-phase extraction, liquid-liquid extraction, affinity capture, and related workflows.
- Support discovery-stage, GLP preclinical, and regulated clinical bioanalysis, including assay execution and transfer to CROs.
- Modernize automation and instrumentation to improve assay throughput and sensitivity while collaborating with multidisciplinary research and development teams.
- Prepare and review study reports, analytical methods, SOPs, technical memoranda, and other regulatory-compliant documentation.
Requirements
- Doctorate degree, or a master’s degree plus 2 years of relevant industrial or technical experience, or a bachelor’s degree plus 4 years of relevant industrial or technical experience.
- Strong technical expertise in quantitative mass spectrometry using triple quadrupole and high-resolution mass spectrometry platforms.
- Experience with bioanalytical sample types such as blood, plasma, serum, tissues, and cerebrospinal fluid.
- Experience with automated or semi-automated sample preparation, including protein precipitation, SPE, affinity capture, and high-throughput workflows.
- Ability to resolve scientific challenges, manage multiple projects and timelines, maintain data integrity, and collaborate with internal and external stakeholders.
- Prior GLP and GCP experience, regulated assay execution, and CRO transfer experience are strongly desired.
Culture & Benefits
- Collaborative, innovative, and science-based work environment.
- Comprehensive health, dental, vision, life, disability, and flexible spending benefits.
- Retirement and savings plan with company contributions.
- Discretionary annual bonus program and stock-based long-term incentives.
- Award-winning time-off plans and career development opportunities.
- Flexible work models may be available where applicable to the role.
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