Clinical Pharmacology Lead (Associate Director) (MIDD)

Location: Cambridge, Massachusetts, United States. Hybrid role requiring residence within commuting distance and on-site work an average of 2.5 days per week or more as needed. Permanent U.S. work authorization is required; U.S. work visa sponsorship is not available.

Annual base salary: $139,100–$231,900, plus a 17.5% bonus target and eligibility for a share-based long-term incentive program.

Company

hirify.global develops medicines and applies model-informed drug discovery and development approaches to support evidence-based drug development.

What you will do

• Represent Clinical Pharmacology on clinical, development, and other multifunctional project teams.
• Design and execute clinical pharmacology plans and end-to-end MIDD strategies for Internal Medicine projects.
• Plan and oversee protocol authoring, clinical phase activities, PK/PD analyses, biomarker and immunogenicity measurement strategies, and study reporting.
• Develop dose-range finding strategies and optimize doses, dosage regimens, and clinical study designs.
• Provide clinical pharmacology contributions to regulatory documents, including IND, NDA/MAA, investigator brochures, briefing documents, and regulatory responses.
• Develop methodologies through internal and external collaborations, publish findings, present at scientific events, and coach less experienced colleagues.

Requirements

• MD, PhD, PharmD, or equivalent training and experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or a related discipline.
• At least 5 years of industry experience in clinical pharmacology, clinical PK/PD, pharmacometrics, or systems pharmacology.
• Strong quantitative expertise in mechanistic PK/PD modeling, systems pharmacology, literature meta-analysis, population modeling, and clinical trial simulations.
• Experience with quantitative pharmacology approaches and tools such as NONMEM and R.
• Leadership, collaboration, coaching, communication, and presentation skills, with the ability to influence multifunctional teams.
• Ability to work in the United States with permanent work authorization; visa sponsorship is not available.

Culture & Benefits

• Hybrid work arrangement with on-site collaboration in Cambridge.
• Opportunities for professional growth and learning within Clinical Pharmacology.
• 401(k) plan with hirify.global matching contributions and an additional retirement savings contribution.
• Paid vacation, holidays, personal days, caregiver/parental leave, and medical leave.
• Medical, prescription drug, dental, and vision coverage.