Associate Director Preclinical & Translational PK/PD

Location: Onsite in Tarrytown, New York, United States

Salary: $176,100–$287,300 annually

Company

hirify.global is a biotechnology company developing and advancing therapeutic medicines through research, quantitative pharmacology, and clinical development.

What you will do

• Develop quantitative and mechanistic PK/PD models supporting preclinical-to-early-clinical translation, human efficacious dose predictions, and first-in-human dose selection.
• Advance the strategic direction of modeling and simulation sciences.
• Support preclinical PK/PD representatives and R&D teams in designing, executing, and interpreting in vitro and in vivo quantitative pharmacology studies.
• Optimize the use of mouse PK data to inform translation to nonhuman primate and human PK.
• Integrate and summarize modeling and simulation analyses for multidisciplinary project teams.
• Present research at scientific meetings and publish findings in scientific journals.

Requirements

• Ph.D. or M.S. in pharmacokinetics, pharmaceutical sciences, engineering, applied mathematics, or a related discipline.
• More than 6 years of pharmaceutical industry or related experience applying mechanism-based PK/PD models to R&D from early discovery through IND-stage clinical development.
• Strong theoretical and practical foundation in non-compartmental, compartmental, PK/PD, and PBPK approaches.
• Experience with modeling and simulation platforms such as Phoenix NLME, NONMEM, Monolix, ADAPT, MATLAB, or SimBiology.
• Ability to collaborate effectively in a fast-paced, highly matrixed environment and use scientific reasoning to influence stakeholders.

Nice to have

• Familiarity with monoclonal and bispecific antibodies, gene therapy, CAR-T, siRNAs, and other targeting agents.
• Ability to learn emerging areas of biological science and develop quantitative, mechanistic PK/PD models for new therapeutic modalities.

Culture & Benefits

• Collaborative, inclusive, and multidisciplinary work environment.
• Potential benefits include bonuses or incentive plans, equity awards, retirement benefits, health and wellness programs, insurance, paid time off, and family support benefits.
• Background checks may verify identity, right to work, and educational qualifications where required by local law.