Scientist, Process Development (Formulation) (Biologics)

Location: Norwood, Massachusetts, United States; 70% in-office work model

Salary: $109,200–$174,600 per year, with potential bonus, incentive compensation, or equity eligibility.

Company

hirify.global develops mRNA medicines and operates a biotechnology platform focused on reimagining how medicines are created and delivered.

What you will do

• Design and execute enzyme formulation studies covering buffers, pH, ionic strength, stabilizers, surfactants, cryoprotectants, concentration, and storage conditions.
• Develop stability, compatibility, and use-condition studies for enzymes used in DNA template manufacturing.
• Evaluate activity, purity, degradation, aggregation, adsorption, concentration recovery, and functional performance under process-relevant conditions.
• Assess robustness during freeze/thaw, hold time, dilution, mixing, temperature exposure, agitation, and contact-material exposure.
• Use biochemical, biophysical, analytical, and DNA process-performance assays to identify risks and troubleshoot activity or stability losses.
• Support technology transfer and manufacturing implementation through technical rationale, handling recommendations, control strategies, protocols, reports, and transfer-ready documentation.

Requirements

• PhD in Pharmaceutical Sciences, Chemical Engineering, Biochemical Engineering, or a related field; alternatively, an MS with 5+ years or BS with 8+ years of relevant industry experience.
• Hands-on experience developing protein, enzyme, biologics, or drug product formulations.
• Strong understanding of protein and enzyme stability and degradation mechanisms, including aggregation, oxidation, deamidation, hydrolysis, precipitation, adsorption, and thermal, freeze/thaw, and interfacial stress.
• Experience designing formulation screens, excipient compatibility studies, forced or accelerated degradation studies, hold-time studies, or use-condition studies.
• Experience with analytical, biochemical, biophysical, or functional assays and interpretation of formulation performance data.
• Must already hold U.S. work authorization and maintain it without future sponsorship; only U.S. persons eligible under applicable export-control requirements.

Nice to have

• Experience with DNA-modifying enzymes, DNA template production, plasmid DNA, synthetic DNA, mRNA, RNA, LNP, oligonucleotide, vaccine, or related nucleic-acid platforms.
• Experience with liquid, frozen, refrigerated, or lyophilized protein and enzyme formulations.
• Experience with chromatography, electrophoresis or CE, UV/Vis, DLS, DSC/DSF, osmolality, pH, subvisible particle analysis, or other stability-indicating methods.
• Experience with high-throughput screening, automation, miniaturized scale-down models, statistical analysis, or DOE.
• Knowledge of technology transfer, CMC documentation, container-closure systems, single-use materials, extractables and leachables, GMP, or GLP.

Culture & Benefits

• In-person collaboration supported by a 70/30 work model emphasizing office-based teamwork and mentorship.
• Healthcare and voluntary benefit programs.
• Fitness, mindfulness, and mental health resources.
• Family planning support, including fertility, adoption, and surrogacy benefits.
• Paid time off including vacation, volunteer days, sabbatical, global recharge days, and year-end shutdown, plus savings and investment programs.