Synthetic DNA Process Development Scientist (Oligonucleotide Synthesis)

Location: Louisville, KY, USA; candidates should live within a commutable distance of Louisville. Full-time schedule is Monday–Friday, 8:00 a.m.–5:00 p.m., with overtime, weekend work, and occasional off-hours support as needed.

Company

hirify.global provides analytical testing, laboratory, genomics, pharmaceutical, environmental, food, cosmetic, and life sciences services through a global network of laboratories.

What you will do

• Design, develop, optimize, and scale chemical synthesis processes for nucleotides and oligonucleotides.
• Develop and improve oligonucleotide purification processes using HPLC, ion exchange, and desalting.
• Troubleshoot synthesis and purification challenges to improve yield and purity.
• Support process transfer from R&D to manufacturing and collaborate with manufacturing, QC, and engineering.
• Evaluate new chemistries and technologies for high-throughput oligonucleotide production.
• Author SOPs, batch records, and technical reports, ensure quality-system compliance, and mentor lab technicians.

Requirements

• Ph.D. or Master’s degree in Organic Chemistry or a related field.
• At least 5 years of industrial experience in chemical synthesis.
• Hands-on experience with solid-phase oligonucleotide synthesis and oligonucleotide purification process development.
• Strong analytical skills with HPLC and LC-MS, plus experience scaling processes to manufacturing.
• Authorization to work indefinitely in the United States without restriction or sponsorship is required.
• Ability to work in a fast-paced environment, manage multiple priorities, and provide occasional off-hours support.

Nice to have

• Experience in GMP or other regulated environments.
• Familiarity with automated DNA/RNA synthesizers.
• Knowledge of modified nucleotides.
• Experience in high-throughput oligonucleotide production.

Culture & Benefits

• Collaborative, fast-paced working environment.
• Comprehensive medical, dental, and vision coverage.
• Life and disability insurance.
• 401(k) with company match.
• Paid vacation and holidays.