Principal Scientist, Oligonucleotide (PMO, ASO) Development

Location: Waltham, MA, United States; onsite presence required 4–5 days per week with no remote option.

Salary: $159,000–$200,000 USD base pay annually.

Company

hirify.global is a clinical-stage biotechnology company developing oligonucleotide therapeutics for genetically driven neuromuscular diseases, including Duchenne muscular dystrophy and myotonic dystrophy type 1.

What you will do

• Lead process development and chemical synthesis strategies for PMO and modified ASO payload molecules from preclinical development through GMP manufacturing.
• Define analytical strategies covering impurity control, raw material specifications, and physicochemical characterization of oligonucleotide payloads and conjugated protein drug substances.
• Manage external CDMOs as the primary technical lead, including technology transfers, assay transfers, data integrity, and issue resolution.
• Drive continuous improvement initiatives and implement emerging technologies to improve product quality, scalability, and manufacturing efficiency.
• Review and approve development and cGMP documentation, including tech-transfer protocols, process characterization documents, master batch records, and campaign summary reports.
• Author and review CMC and product-related sections for regulatory submissions, including IND and IMPD Module 3 content.

Requirements

• Bachelor’s degree in biochemistry, chemical engineering, chemistry, pharmaceutical sciences, or a related field.
• 8+ years of relevant pharmaceutical or biotechnology industry experience; an advanced degree is preferred.
• Proven expertise in process chemistry and development of PMO and modified ASO oligonucleotides, including synthesis and purification.
• Experience with analytical development, impurity control strategies, and physicochemical characterization of payloads and conjugated drug substances.
• Direct experience overseeing CDMOs and managing technology transfers.
• Strong problem-solving, communication, and cross-functional leadership skills across internal teams, contractors, and third-party vendors.

Culture & Benefits

• Work in a clinical-stage biotechnology environment focused on life-transforming treatments for neuromuscular diseases.
• Collaborate within a matrixed organization across research, development, regulatory, quality, and external manufacturing partners.
• Contribute to proprietary oligonucleotide delivery and bioconjugation platform development.
• Work is structured as a full-time onsite position in Waltham, Massachusetts.