Principal Scientist, In-vivo CAR-T

Location: On-site in Malvern, Pennsylvania, United States

Company

Johnson & Johnson MedTech develops healthcare innovations and therapies across Innovative Medicine and MedTech.

What you will do

• Lead, design, and execute lentiviral vector process development studies across early- and late-stage development.
• Perform hands-on laboratory work involving process design, optimization, and characterization.
• Analyze and interpret data to improve process understanding, robustness, and decision-making.
• Support process characterization, including identification of critical process parameters and development of robust processes.
• Contribute to scale-up, manufacturing readiness, and technology transfer to internal sites or contract manufacturing organizations.
• Collaborate with Analytical Development, MSAT, Quality, Manufacturing, Regulatory, modelling, and data science teams.

Requirements

• Ph.D. with 2–4 years of relevant experience, or a B.S./M.S. with 6–8 years of experience in life sciences, chemical engineering, or a related scientific discipline.
• Experience in viral vector process development and/or lentiviral vector formulation development.
• Strong hands-on laboratory experience in drug product or viral vector development.
• Understanding of process scale-up, technology transfer, GxP principles, and data integrity requirements.
• Strong scientific problem-solving, data interpretation, communication, and prioritization skills.
• Ability to work effectively and collaborate in a cross-functional, matrixed development environment.

Nice to have

• Experience with lentiviral vector platforms, viral vectors, or advanced therapies.
• Familiarity with process validation, including LCPV, and manufacturing support.
• Exposure to early- and late-stage development or commercial readiness activities.

Culture & Benefits

• Full-time employment with an inclusive work environment.
• Cross-functional collaboration across scientific, manufacturing, quality, analytical, and regulatory disciplines.
• Commitment to equal employment opportunity and an accessible interview process.