Molecular Biology Scientist/Senior Associate Scientist

TL;DR

Molecular Biology Scientist/Senior Associate Scientist: Supporting lentiviral vector (LVV) design, construction, and functional evaluation, plus engineered cell line development for CAR-T and other cell therapy programs with an accent on reliable experimental execution, timely material delivery, and clear data communication. Focus on molecular cloning, mammalian cell engineering, BSL-2 compliant workflows, and assay-driven vector performance characterization.

Location: Philadelphia, PA

Salary: $93,463 - $122,670 USD (base pay)

Company

hirify.global is a global biotechnology company developing advanced cell therapies and immunotherapies for life-threatening diseases.

What you will do

• Design and construct viral vector plasmids and helper plasmids to support gene overexpression, knock-down, and knock-out studies.
• Perform routine molecular cloning workflows and ensure plasmid quality meets QC standards for vector production.
• Generate and characterize engineered mammalian cell lines for transient or stable viral vector production, including single-cell cloning and basic characterization.
• Execute mammalian cell culture and transient transfection under BSL-2 conditions and support small-scale vector production using suspension cell lines.
• Evaluate vector performance using qPCR/dPCR, ELISA/Western Blot, and flow cytometry; analyze data and communicate conclusions and next steps.
• Maintain compliant electronic lab notebooks (ELN), sample tracking, and inventory/recordkeeping; collaborate on tech transfer activities as needed.

Requirements

• Scientist: M.S. with 5+ years or Ph.D. with 0-2 years in a related field; hands-on molecular cloning, cell engineering, and mammalian cell culture required.
• Hands-on molecular biology experience (cloning, plasmid prep, sequence analysis, and construct verification).
• Experience with mammalian cell culture and transient transfection; familiarity with BSL-2 practices and documentation.
• Experience generating engineered cell lines (stable expression and/or CRISPR KO/KI) including cloning and basic screening.
• Experience with viral vector production/workflows (LVV preferred) and functional readouts (e.g., transduction efficiency and gene expression).
• Experience with qPCR/dPCR, flow cytometry, Western blot, and ELISA; strong ELN documentation, sample tracking, and ability to follow SOPs with attention to detail.

Culture & Benefits

• Medical, dental, and vision insurance plus a 401(k) retirement plan with company match.
• Eight (8) weeks of paid parental leave after three (3) months of employment.
• Paid time off including vacation, personal time, sick time, floating holidays, and eleven (11) company holidays.
• Flexible spending and health savings accounts, life and AD&D insurance, disability coverage, and additional supplemental plans.
• Benefits are offered exclusively to permanent full-time employees (contractors are not eligible).

Hiring process

• Interviews and evaluation based on molecular biology and viral vector/cell engineering experience.
• Assessment of documentation practices and ability to communicate experimental results and next steps.