Staff Scientist, Machine Learning (Genomics)

Location: US Remote; United States

Salary: USD 167,400–209,200 per year

Company

hirify.global develops cell-free DNA testing and personalized genetic diagnostics for oncology, women’s health, and organ health.

What you will do

• Lead research on machine learning and deep learning models using NGS data and set technical direction for ambiguous problems.
• Design, build, benchmark, and validate models and features for Women’s Health and Organ Health products.
• Run, interpret, debug, and extend sequencing bioinformatics pipelines, tracing issues through processing steps, data, and biology.
• Partner with molecular biology and assay development scientists on study design, controls, data generation, and experimental troubleshooting.
• Set standards for validation, performance estimation, leakage prevention, analysis, and technical documentation.
• Contribute to invention disclosures, patents, publications, and presentations while mentoring data scientists and bioinformaticians.

Requirements

• M.S. or Ph.D. in computer science, applied mathematics, statistics, bioinformatics, computational biology, engineering, or a related quantitative field; equivalent professional depth is accepted.
• 6+ years of hands-on machine learning and biological or genomic data analysis experience after the degree, including experience from the point at which work became substantially independent.
• Track record of leading models or algorithms that reached real use in a product, production pipeline, or relied-upon decision.
• Depth in NGS data analysis, including sequencing QC, alignment, quantification, normalization, and sequencing artifacts.
• Ability to independently run, read, debug, interpret, and extend NGS bioinformatics pipelines and their components.
• Extensive practical experience with machine learning, deep learning, statistics, model validation, and performance estimation on limited or imbalanced data.
• Advanced Python and experience with open-source machine learning libraries such as scikit-learn, PyTorch, TensorFlow, or XGBoost in a cloud environment.
• Experience processing large datasets and using a query language such as SQL.
• Ability to apply mathematical and statistical principles to estimation problems, understand molecular or clinical biomarker assay pipelines, communicate technical results clearly, and deliver complex cross-functional projects.

Nice to have

• RNA-seq or small RNA/miRNA experience.
• Probabilistic modeling for NGS and omics data.
• Diagnostic product development in a regulated or CLIA/CAP setting.
• Workflow orchestration with Nextflow, WDL, or Snakemake, and containerization with Docker.
• AWS or GCP experience for large-scale machine learning training and inference.
• Patents, peer-reviewed publications, or conference presentations.
• Experience working in a fast-paced, high-impact small-team environment.

Culture & Benefits

• Remote work is available within the United States.
• Benefits include medical, dental, vision, life, and disability plans for eligible employees and dependents.
• Additional benefits include free testing for employees and immediate families, fertility care, pregnancy and baby bonding leave, 401(k), commuter benefits, and an employee referral program.
• AI tools, including coding agents for implementation, analysis, and review, are part of routine work; ownership of shipped output remains with the employee.
• hirify.global promotes inclusive collaboration and equal employment opportunity.