Senior Scientist I, Biotherapeutic Production Technologies

Location: Andover, Massachusetts, United States

Base salary: $125,000–$175,000 per year, plus annual bonus, equity compensation, and benefits.

Company

hirify.global is a clinical-stage generative biology company using machine learning and large-scale experimentation to design proteins and develop next-generation biologic medicines.

What you will do

• Define, plan, and execute protein production, purification, and characterization strategies across discovery and platform initiatives.
• Design, optimize, scale, and troubleshoot transient mammalian and cell-free protein expression workflows, with technical input into construct design and molecular biology.
• Develop purification workflows from capture through polishing, including chromatography screening, resin selection, operating-condition optimization, and scale translation.
• Produce protein material across formats and scales and establish fit-for-purpose quality attributes and acceptance criteria.
• Select and interpret analytical and biochemical methods for assessing purity, identity, concentration, oligomeric state, aggregation, stability, and related quality attributes.
• Integrate data, resolve technical challenges, communicate recommendations, lead external-partner interactions, and advance scalable, reproducible, automated, high-throughput, and AI/ML-enabled workflows.

Requirements

• Ph.D. in biochemistry, molecular biology, bioengineering, chemical engineering, protein sciences, or a related discipline, with typically 4 or more years of relevant industry experience; or a relevant B.S. or M.S. with typically 12 or more years of relevant industry experience; or equivalent experience demonstrating the required technical depth, independent judgment, and scope of impact.
• Demonstrated ability to independently lead complex protein production, purification, and characterization strategies and establish milestones, decision criteria, dependencies, and risk-mitigation plans.
• Experience with protein expression workflows, including transient mammalian and cell-free protein synthesis platforms, as well as purification from capture through polishing.
• Experience designing and interpreting chromatography studies, selecting resins, optimizing operating conditions, and translating processes to scale.
• Ability to apply analytical and biochemical characterization methods and integrate expression, purification, and characterization data into technical recommendations.
• Ability to collaborate cross-functionally and lead technical work with CROs, CDMOs, vendors, and other external partners.
• Ability to communicate evidence, assumptions, risks, uncertainty, progress, setbacks, and recommendations clearly and transparently.

Nice to have

• Experience with stable-expression systems, stable cell-line development, construct design, cloning, vector design, or related molecular-biology workflows.
• Experience with engineered proteins, multispecifics, novel scaffolds, or other complex protein modalities.
• Experience integrating protein design information into expression, purification, or characterization strategies.
• Experience with automation, high-throughput experimentation, laboratory information systems, or structured experimental-data environments.
• Experience managing CRO, CDMO, or vendor technical work.
• Experience developing workflows or methods adopted beyond an immediate project or work group.

Culture & Benefits

• Individual-contributor role with broad technical ownership and cross-functional collaboration across discovery, platform, analytical, and data-focused partners.
• Opportunity to improve the speed, quality, scale, and reproducibility of protein-production workflows in a data-rich discovery environment.
• Annual bonus, equity compensation, and a competitive benefits package.
• Equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or veteran status.
• Unsolicited resumes from recruitment or staffing agencies are not accepted unless the agency is contacted directly by hirify.global' internal Talent Acquisition team.