Senior Principal Scientist (Quantitative Biosciences)

Location: Boston, Massachusetts, United States of America; onsite role. Relocation: Domestic/International. Visa sponsorship: Yes.

Salary: $214,100–$337,000 annual base salary, plus potential annual bonus and long-term incentive.

Company

hirify.global is a pharmaceutical and biotechnology company developing medicines through multidisciplinary research and discovery programs.

What you will do

• Lead the Boston mass spectrometry group supporting in vitro and in vivo pharmacology and serve as a scientific partner to Quantitative Biosciences discovery teams.
• Shape strategy for mass spectrometry-enabled assay development, experimental design, data interpretation, and quantitative pharmacology across discovery programs.
• Develop and execute mass spectrometry-based assays supporting mechanism, potency, selectivity, exposure-response, and translational decisions.
• Guide assay selection, study design, mechanistic interpretation, and data-driven recommendations for multidisciplinary project teams.
• Build connections across the Boston organization and global Quantitative Biosciences network to strengthen consistency and deployment of mass spectrometry capabilities.
• Mentor scientists, communicate scientific concepts to technical and non-technical stakeholders, and influence decisions across organizational boundaries.

Requirements

• Ph.D. or equivalent in biology, pharmacology, analytical chemistry, biochemistry, pharmaceutical sciences, or a related STEM discipline with 12+ years of relevant experience; or MS with 15+ years; or BS with 16+ years.
• Deep expertise in mass spectrometry-based assay development and its application to drug discovery.
• Strong understanding of hit finding, hit-to-lead, lead optimization, and pharmacology-driven decision-making.
• Experience applying quantitative pharmacology principles to interpret biological systems and guide experimental strategy.
• Scientific leadership experience in a biopharmaceutical setting, demonstrated through impact on discovery programs, publications, external scientific reputation, or internal platform advancement.
• Experience leading, managing, mentoring, or developing scientists in a research environment.
• Experience independently designing experiments, interpreting complex data, and translating findings into clear project recommendations.
• Ability to simplify complex scientific challenges into actionable strategies and influence alignment across multidisciplinary teams.
• Excellent written and verbal communication skills, strong organization, self-motivation, prioritization across multiple projects, and ability to work across sites, functions, and organizational boundaries.
• Experience integrating mass spectrometry readouts with pharmacology, biology, DMPK, or translational science to support discovery decisions.

Culture & Benefits

• Collaborative, multidisciplinary environment with local and global scientific partnerships.
• Culture focused on scientific rigor, critical thinking, inclusion, open dialogue, and collective problem-solving.
• Medical, dental, vision, and other insurance benefits for employees and families.
• Retirement benefits including 401(k), paid holidays, vacation, compassionate leave, and sick days.
• Annual bonus and long-term incentive eligibility where applicable.