Principal Scientist, Bioinformatics (AI)

Location: Somerset, New Jersey, United States; onsite. Applicants must be authorized to work in the United States.

Base pay: $146,410–$192,164 USD per year. Performance-based bonus and/or equity may be available for eligible roles.

Company

hirify.global is a biotechnology company developing cell-based therapies, including CAR-T, TCR-T, NK cell-based, and other emerging platforms.

What you will do

• Architect and deploy agentic AI systems to mine multi-omic datasets, clinical literature, and biological pathways for novel tumor-specific drug targets.
• Build predictive frameworks using transcriptomics and other datasets to evaluate target druggability and potential off-tumor toxicity.
• Develop and adapt generative models, including protein language models, diffusion models, and inverse-folding algorithms, to design specific binders for tumor antigens.
• Use geometric deep learning and structural biology to model paratope-epitope interactions and support CAR-T binder design.
• Inspect and refine AI-designed binders by addressing physical anomalies, steric clashes, backbone strain, hydrophobic packing, and hydrogen-bonding networks.
• Optimize binder biophysical properties to support CAR-T signaling and prevent T-cell exhaustion.

Requirements

• Ph.D. in Computational Biology, Computer Science, Structural Biology, or Biophysics.
• 3+ years of post-Ph.D. experience, or 6+ years for MS/BS, in the biotechnology or pharmaceutical industry or an advanced research setting focused on computational drug discovery, target identification, and antibody or binder design.
• Expert programming proficiency in Python and deep learning frameworks, primarily PyTorch.
• Experience building generative AI models and agentic AI systems using LLM orchestration frameworks to query biomedical databases and literature.
• Deep familiarity with AlphaFold, ESMFold, RFdiffusion, ProteinMPNN, BindCraft, and FoldFlow.
• Proficiency with physics-based simulation and structural optimization or visualization tools, including GROMACS, AMBER, OpenMM, and PyMOL.
• Solid understanding of structural immunology and expertise in interface biophysics, including calculating interface binding energies (ΔΔG) and evaluating electrostatic surface potentials.
• Familiarity with multi-omics platform datasets and target evaluation databases, including TCGA, Open Targets, Human Protein Atlas, and DepMap.

Culture & Benefits

• Permanent full-time employees receive medical, dental, and vision insurance.
• Benefits include a 401(k) retirement plan with a company match that fully vests on day one.
• Eight weeks of paid parental leave are available after three months of employment.
• Paid time off includes vacation, personal time, sick time, floating holidays, and eleven company holidays.
• Additional benefits include flexible spending and health savings accounts, disability coverage, life and AD&D insurance, commuter benefits, family planning and care resources, and well-being initiatives.
• Contractors are not eligible for benefits through hirify.global.