Principal Scientist, Pharmacokinetics, Biologics

Location: Boston, Massachusetts, United States; based at research laboratories. Travel requirements: 10%. Flexible work arrangements: not applicable.

Salary: $176,200–$277,300 annually, plus eligibility for annual bonus and long-term incentive where applicable.

Company

hirify.global is a global healthcare and pharmaceutical company developing prescription medicines, vaccines, and animal health products.

What you will do

• Lead bioanalytical strategies for a portfolio of biologics drug discovery programs, including monoclonal antibodies, bispecifics, and engineered proteins.
• Manage and develop a team of PDMB scientists delivering ligand binding assays and mass spectrometry-based bioanalytical strategies.
• Represent project teams and serve as a subject matter expert across multidisciplinary DMPK activities.
• Support oncology and immunology programs, with potential contributions to cardiovascular/metabolic, neuroscience, and infectious disease efforts.
• Design and evaluate bioanalytical approaches, interpret PK and PK/PD datasets, and communicate findings internally and at external conferences.
• Collaborate with discovery and early development teams in Boston, South San Francisco, and West Point to develop efficient strategies for identifying and optimizing drug candidates.

Requirements

• Ph.D. with 6+ years of relevant experience or a Master’s degree with at least 10 years of relevant experience in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering, or a related field.
• Experience leading bioanalytical strategies for biologics, including ligand binding assays and mass spectrometry, method development, data generation, interpretation, and report writing.
• Technical ability to analyze, interpret, and contextualize pharmacokinetic, pharmacodynamic, biomarker, or immunogenicity data for biologics, drug conjugates, and peptides.
• Experience developing and executing translational PK/PD/efficacy relationships and other quantitative pharmacology applications in a discovery setting.
• Management experience, including mentoring and talent development of multiple direct reports.
• Strong leadership, interpersonal, communication, problem-solving, and collaboration skills.
• A record of increasing responsibility and independence in a similar industrial or academic setting.

Nice to have

• Hands-on experience with translational PK/PD/efficacy and physiologically based pharmacokinetic modeling using tools such as Phoenix WinNonlin, Berkeley Madonna, or MATLAB.
• Experience supporting immunology or oncology programs from early discovery through IND-enabling efforts.
• Familiarity with engineering strategies for improving the pharmacokinetic and pharmacodynamic properties of protein therapeutics.
• Experience working within a research-driven pharmaceutical company.

Culture & Benefits

• Research-driven environment focused on scientific excellence, innovation, integrity, respect, and collaboration.
• Opportunities to collaborate with multidisciplinary colleagues and develop scientific and technical skills.
• Medical, dental, vision, and other insurance benefits for employees and families.
• Retirement benefits including a 401(k), paid holidays, vacation, compassionate leave, and sick days.
• Regular employee status; visa sponsorship is available.