Principal Scientist - Therapeutic Antibody Characterization (Biotech)

Location: Berkeley, California, United States; flexible remote and hybrid working arrangements may be available where possible.

Salary: $166,000–$191,000 annually, depending on experience, plus benefits.

Company

hirify.global is a pre-IPO biotechnology company integrating human biology, machine learning, scalable biology, and 3D-printed human lymph node organoids to develop next-generation antibody therapeutics.

What you will do

• Lead analytical characterization of monoclonal antibodies, bispecific antibodies, Fc-fusion proteins, and related biologics.
• Conduct developability and biophysical assessments using Tm, Tagg, particle size analysis, AC-SINS, HIC, cIEF, analytical SEC, and BVP assays.
• Generate, analyze, and interpret data for lead candidate selection, formulation development, stability studies, and analytical comparability.
• Design, execute, troubleshoot, and optimize analytical methods for therapeutic protein characterization.
• Prepare technical reports and present experimental findings to cross-functional project teams.
• Collaborate with Antibody Discovery, Protein Engineering, and CMC teams while maintaining accurate laboratory documentation and safety standards.

Requirements

• Ph.D. or M.S. in Biochemistry, Chemistry, Molecular Biology, Pharmaceutical Sciences, or a related discipline.
• At least 3 years of industry experience characterizing therapeutic antibodies, bispecific antibodies, Fc-fusion proteins, or other biologics.
• Hands-on experience with Tm, Tagg, AC-SINS, HIC, cIEF, analytical SEC, BVP, and related biochemical and biophysical assays.
• Ability to independently design experiments, analyze data, troubleshoot technical challenges, and communicate scientific findings.
• Strong organizational, interpersonal, written communication, and multidisciplinary collaboration skills.

Nice to have

• Experience with antibody developability, stability profiling, and analytical comparability studies.
• LC-MS characterization, including intact mass analysis, subunit analysis, peptide mapping, and PTM analysis.
• Bioanalysis of serum and plasma samples for PK, PD, and preclinical studies.
• Characterization of antibody–peptide drug conjugates, including conjugation analysis, purity, drug loading, and stability.
• Knowledge of regulatory expectations and analytical strategies for therapeutic biologics development.

Culture & Benefits

• Team-oriented, inclusive, and family-friendly work environment.
• Medical, dental, and vision coverage, life and disability insurance, flexible spending accounts, and a 401(k) plan.
• Stock-based long-term incentives.
• Holiday package including a winter shutdown of more than one week.
• Flexible work models, including remote and hybrid arrangements where possible.