Senior Scientist, ADC In Vivo Pharmacology (ADC)

Location: On premise in San Diego, California, United States. Candidates must have permanent U.S. work authorization and be authorized to work in the U.S. by any employer. Relocation support may be available based on business needs and eligibility.

Annual base salary: $88,500–$147,500, plus eligibility for a 10% performance bonus.

Company

hirify.global conducts pharmaceutical research and development, including oncology programs focused on antibody-drug conjugates.

What you will do

• Lead in vivo pharmacology strategy for ADC discovery programs from early discovery through preclinical development.
• Design, oversee, and interpret efficacy, dose optimization, tolerability, pharmacodynamic biomarker, mechanism-of-action, and combination studies.
• Translate program questions into experimental plans and decision-enabling study packages.
• Integrate tumor models, antigen expression, payload biology, linker-payload properties, PK/PD hypotheses, and translational endpoints.
• Coordinate internal and external studies, including protocols, CRO management, data review, quality control, and final interpretation.
• Communicate scientific findings to multidisciplinary project teams and mentor junior scientists and technical staff.

Requirements

• Advanced degree in pharmacology, cancer biology, immunology, biological sciences, or a related field, or a bachelor's/master's degree with substantial relevant industry experience.
• Experience designing and leading in vivo oncology pharmacology studies in pharmaceutical, biotechnology, academic, or CRO settings.
• Strong understanding of ADC biology and pharmacology, including target antigen biology, payload classes, therapeutic index, efficacy/tolerability relationships, and translational biomarkers.
• Experience interpreting tumor efficacy, tolerability, pharmacodynamic, biomarker, and dose-response data.
• Ability to manage multiple priorities, coordinate internal and external resources, communicate complex scientific data, and influence project strategy.
• U.S. work authorization is required; U.S. work visa sponsorship is not available.

Nice to have

• Experience supporting ADC programs through candidate selection or IND-enabling stages.
• Experience with patient-derived or cell line-derived xenograft, orthotopic, or disseminated disease models.
• Familiarity with bioanalytical, pathology, immunohistochemistry, molecular profiling, or omics approaches.
• Experience managing CRO budgets, timelines, study plans, and data review workflows.
• Contributions to regulatory-enabling packages, governance presentations, publications, or scientific strategy documents.

Culture & Benefits

• On-premise work within the Oncology Research Unit and cross-functional project teams.
• Opportunity to mentor junior scientists and improve oncology in vivo workflows and translational relevance.
• Comprehensive benefits including 401(k) matching and retirement contributions.
• Paid vacation, holidays, personal days, caregiver/parental leave, and medical leave.
• Medical, prescription drug, dental, and vision coverage.