Senior Research Associate, Cell Culture

Location: Waltham, Massachusetts, United States. Onsite laboratory work is required, with travel to CDMO sites and conferences up to 10% of the time.

Company

hirify.global is a clinical-stage biotechnology company developing antibody-based therapies for kidney, immune-mediated, and other hard-to-treat diseases as part of the Otsuka family of companies.

What you will do

• Conduct shake flask and bench-scale bioreactor experiments for cell culture process development and characterization.
• Execute cell line development workflows, including producer cell line generation, genetic stability testing, and Research Cell Bank establishment.
• Prepare DNA vectors using homology-based cloning, bacterial transformation and propagation, and kit-based purification.
• Monitor and sample cell culture processes, evaluating viability, cell density, metabolites, pH, and related attributes.
• Support technology transfer, scale-up calculations, process troubleshooting, GMP manufacturing, batch record review, and deviation investigations.
• Document experimental results, present data to cross-functional teams, maintain laboratory equipment, and represent hirify.global at CDMO sites.

Requirements

• B.S. in Pharmaceutical Sciences, Biochemistry, Biology, Chemical Engineering, Biological Engineering, or a related discipline with 3 years of relevant industry experience, or an M.S. with 1 year of relevant industry experience.
• Experience maintaining and troubleshooting mammalian cell culture operations, including aseptic techniques.
• Strong understanding of cell culture parameters, including growth rate, density, viability, population doubling, metabolites, and cell waste.
• Hands-on experience with mammalian cell transfection for transient and/or stable gene expression.
• Ability to work independently, prioritize work, meet deadlines, and communicate effectively with internal and external stakeholders.
• Some work outside standard hours, including weekends, is required due to cell culture activities.

Culture & Benefits

• Work in a small, dynamic biotechnology organization supported by the resources and stability of a global pharmaceutical company.
• Collaborate with Quality Assurance, Research, Regulatory, CDMO, and other external partners.
• Participate in department, cross-functional, and drug development team meetings.
• Travel to global manufacturing sites and conferences up to 10% of the time.
• Access opportunities to apply new technologies to improve process development capabilities.