Manager, Upstream Pilot Plant (Gene Therapy)

Location: San Diego, California, United States; full-time, in-person presence required.

Salary: $124,000–$161,000 annual.

Company

hirify.global is a global biopharmaceutical company developing products for patients with serious and rare diseases.

What you will do

• Execute upstream processes including cell culture expansion, seed train operations, bench-, pilot-, and production-scale bioreactor operations, and media/buffer preparation.
• Operate and maintain wave/rocking platforms, stirred-tank bioreactors, incubators, and automated control systems.
• Prepare, sterilize, and manage cell culture consumables while maintaining aseptic technique.
• Prepare, review, and maintain batch records, SOPs, logbooks, raw material specifications, technology transfer documents, and campaign reports.
• Support facility readiness, inspections, scale-up, technology transfer, and continuous improvement initiatives.
• Provide upstream process subject matter expertise and support manufacturing activities, investigations, and assigned deliverables.

Requirements

• Bachelor’s degree in Biology, Chemical Engineering, Biochemistry, or a related field.
• At least five years of experience in upstream process development or manufacturing support in bioprocessing.
• Hands-on experience with mammalian or microbial cell culture, seed train expansion, bioreactor operations, and media/buffer preparation.
• Knowledge and application of current Good Manufacturing Practices (cGMP) and Good Documentation Practices (GDP).
• Experience with manufacturing investigations, root cause analysis, and deviation resolution in biologics production.
• Ability to work full-time in person at the San Diego office.

Nice to have

• Experience conducting manufacturing investigations in biologics or cell-culture-based production.

Culture & Benefits

• Purpose-driven environment focused on serious and rare diseases and meaningful scientific progress.
• Medical, dental, vision, and mental health support, plus annual wellbeing reimbursement and an Employee Assistance Program.
• Paid time off, fertility and family-forming benefits, caregiver support, and flexible schedules with purposeful in-person collaboration.
• 401(k) with company match, annual equity awards, ESPP, and company-paid life and disability insurance.
• Learning resources, workshops, leadership programs, mentoring, employee resource groups, and service opportunities.