Director, Clinical Pharmacology (Oncology)

Location: London or Oxford (Milton Park), United Kingdom; remote work is considered, with regular on-site visits required for routine work and departmental events.

Annual base salary: £118,300–£136,500, plus annual bonus, equity compensation, and benefits.

Company

hirify.global is a clinical-stage TechBio company using an AI-native platform to develop investigational medicines for oncology, rare disease, neuroscience, immunology, and other areas of unmet need.

What you will do

• Lead clinical pharmacology and pharmacometric strategies for a portfolio of rare disease and oncology clinical programs.
• Serve as the clinical pharmacology lead for development programs and represent the function in regulatory interactions.
• Provide pharmacology input into Phase 1–3 clinical study designs and dedicated clinical pharmacology studies.
• Author clinical pharmacology sections of Investigator’s Brochures, INDs, NDAs, and other regulatory submissions.
• Oversee or perform modeling and simulation to support dose selection, exposure-response, and exposure-safety decisions.
• Collaborate with clinical development, translational, preclinical, DMPK, biomarker, regulatory, biostatistics, and due diligence teams.

Requirements

• Ph.D. in Pharmaceutical Sciences, Pharmacokinetics, or a related discipline; or an M.D. with clinical pharmacology expertise; or a Pharm.D. with a clinical pharmacology fellowship.
• 5–9+ years of experience in biotech or pharmaceutical drug development.
• Demonstrated success leading clinical pharmacology aspects of drug development.
• Experience with PK, PK-PD, and PK-safety analyses, including non-compartmental analysis, population PK modeling, and PK-PD modeling and simulations.
• Proficiency with WinNonlin, Monolix, NONMEM, R, or other modeling software.
• Experience responding to regulatory agency questions, preparing regulatory submissions, and attending regulatory meetings.

Nice to have

• Experience in oncology.

Culture & Benefits

• End-to-end collaboration across discovery and clinical development.
• Work with clinical pharmacology, pharmacometrics, translational modeling, and clinical biomarker functions.
• Annual bonus and equity compensation.
• Comprehensive benefits package.
• Values emphasize scientific integrity, active learning, urgency, accountability, and cross-functional collaboration.