Principal Scientist (LC-MS/MS)

TL;DR

Principal Scientist (LC-MS/MS): Leading the development, validation, and application of LC-MS/MS methods for bioanalytical studies within a regulated CRO environment with an accent on mass spectrometry and GxP compliance. Focus on ensuring data integrity, optimizing analytical workflows, and providing scientific oversight for clinical pharmacology and oncology studies.

Location: Merthyr Tydfil, United Kingdom (Office Based)

Company

hirify.global is a full-service CRO specializing in clinical pharmacology, oncology, and rare diseases, providing scalable clinical development solutions for small and mid-size drug developers.

What you will do

• Lead the development, validation, and application of LC-MS/MS methods for bioanalytical studies.
• Ensure all laboratory activities are delivered in compliance with GCP, GLP, and GMP standards.
• Provide scientific oversight of studies, including data review, interpretation, and reporting to regulatory standards.
• Coordinate analytical studies from client onboarding to final reporting, ensuring scientific integrity.
• Mentor scientific staff and act as a technical subject matter expert and escalation point.
• Support business development and represent the department at conferences and trade shows.

Requirements

• Degree in a scientific discipline (advanced qualification desirable).
• Extensive experience using LC-MS/MS in a regulated laboratory environment (GCP, GLP, GMP).
• Proven track record of leading LC-MS/MS-based studies, including method development and validation.
• Deep technical expertise in mass spectrometry instrument setup, optimization, and troubleshooting.
• Strong understanding of bioanalytical method validation requirements and GxP data integrity.
• Excellent communication skills for engaging with internal teams, clients, and stakeholders.

Nice to have

• MSc or PhD in a relevant scientific discipline.
• Experience within a CRO or clinical trial environment.
• Knowledge of MHRA Phase I Accreditation scheme requirements.
• Project management or Lean/Six Sigma certification.
• Experience supporting audits, inspections, and regulatory submissions.

Culture & Benefits

• Opportunity to work with truly innovative drugs for patient populations with serious unmet medical needs.
• Collaborative environment working alongside experts from all clinical development disciplines.
• Career development in challenging therapeutic areas such as rare diseases and oncology.
• Permanent full-time employment.