Senior Scientist – In Vitro Neuroimmunology (Neuroscience)

Location: Boston, Massachusetts, United States; 90% of time in the lab

Salary: $119,100–$187,500 annual base salary, plus potential annual bonus and long-term incentive.

Company

hirify.global develops pharmaceutical therapies, including immune-based treatments for CNS diseases.

What you will do

• Develop, execute, troubleshoot, and characterize cell-based assays, protocols, analysis methods, and in vitro disease models.
• Design and lead complex experimental programs, interpret multidimensional datasets, and provide recommendations influencing research strategy and decisions.
• Isolate and characterize tissues, whole blood, PBMCs, and iPSC-derived cell populations using molecular and cellular biology techniques.
• Provide scientific oversight for external research activities, including study design, protocol review, data interpretation, and integration of findings.
• Communicate scientific results through reports, presentations, publications, and collaboration across disciplines.
• Evaluate literature, competitive intelligence, emerging technologies, and novel model systems to support research innovation.

Requirements

• Ph.D. in Molecular Cell Biology, Neuroscience, Pharmacology, Biology, or a related field, with post-doctoral or industry experience.
• Extensive experience with CNS iPSC cell culture, including construction of complex in vitro tri-culture models.
• Experience culturing immune cell lines, primary murine microglia, and iPSC-derived microglia.
• Recognized expertise in designing, executing, and interpreting complex in vitro and translational studies for target validation, therapeutic strategy, and drug discovery.
• Strong data analysis skills and willingness to leverage AI tools for quality control of small and large datasets.
• Experience with DNA transfection, viral delivery, immunocytochemistry, tissue and cellular protein/RNA preparation, quantitative PCR, western blots, and ELISAs.
• Excellent oral and written communication skills, including study reports, presentations, and manuscripts for peer-reviewed journals.
• Demonstrated scientific innovation, thought leadership, problem solving, and contributions evidenced by publications, presentations, patents, technology development, or drug discovery programs.
• Ability to work 90% of the time in the laboratory.

Nice to have

• Primary neuronal or astrocyte culture experience.
• Experience applying high-content imaging to cell-based assays.
• Experience with small molecules, antibodies, peptides, and siRNA.
• Experience in neuroscience and pharmaceutical research, especially Alzheimer’s, Parkinson’s, or ALS.

Culture & Benefits

• Regular employee position with medical, dental, vision, insurance, retirement, and 401(k) benefits.
• Paid holidays, vacation, compassionate leave, and sick days.
• Collaborative, inclusive environment supporting scientific dialogue, diverse perspectives, and cross-disciplinary problem solving.
• No travel required; flexible work arrangements are not applicable.
• Visa sponsorship is not available.