Principal Scientist Chemistry, Small Molecule Process Development and Manufacturing

Location: Cambridge, MA, United States; on campus

Base compensation: $159,000–$219,000 per year

Company

hirify.global is a mid-sized biotechnology company developing medicines across multiple therapeutic modalities.

What you will do

• Lead collaborative laboratory experimentation to optimize, characterize, and improve the robustness and productivity of small-molecule manufacturing processes.
• Design experimental plans and guide project teams in implementing safe, efficient, and robust chemical processes for drug candidates.
• Develop process knowledge to support scale-up from laboratory operations to manufacturing partners.
• Collaborate with Process Chemistry, Analytical Chemistry, Solid Form, Oligo, and Separations teams on process controls, clinical material supply, and regulatory filings.
• Communicate research results, contribute to CMC sections of INDs, and interact with contract research and manufacturing organizations, including possible travel.
• Mentor less experienced staff, initiate innovative research, and represent hirify.global at external consortia and conferences.

Requirements

• Ph.D. with 8+ years of relevant experience; alternatively, an M.S. with 10+ years or a B.S. with 12+ years of relevant experience in pharmaceutical or biotech settings.
• Strong theoretical and practical background in pharmaceutical chemistry, including route scouting and mechanistic experiments.
• Experience with process characterization, process safety, tech transfer protocols, and effective problem solving.
• Experience with CDMO management.
• Strong communication skills and ability to work collaboratively in a team-oriented environment.

Nice to have

• Experience piloting, manufacturing, and isolating APIs across several modalities.
• Familiarity with analytical tools and varied purification techniques.

Culture & Benefits

• Full-time employment in an on-campus biotechnology environment focused on collaboration, inclusion, accountability, integrity, and scientific excellence.
• Medical, dental, vision, life, short- and long-term disability insurance, fitness and wellness programs, and a 401(k) with company matching.
• At least 15 vacation days, year-end shutdown time, company holidays, personal-significance days, sick time, and paid parental leave.
• Short- and long-term incentives, cash bonus and equity opportunities, employee stock purchase plan, and tuition reimbursement of up to $10,000 per year.