Research Associate in Ubiquitin Signalling (Protein Biochemistry)

Location: Manchester, Greater Manchester, United Kingdom; hybrid working arrangements may be considered. The role is based at the hirify.global on Oxford Road.

Salary: £38,448–£41,885 per annum, depending on relevant experience.

Company

hirify.global research group studying ubiquitin and ubiquitin-like signalling through biochemical, structural, and cellular approaches.

What you will do

• Support a BBSRC-funded programme developing precision tools to dissect ubiquitin signalling.
• Study how polyubiquitin chains with different linkages encode cellular signals.
• Develop a nanobody toolkit for recognising polyubiquitin chains through selection and engineering.
• Apply protein biochemistry, quantitative binding assays, and cellular methods to ubiquitin biology.
• Work with structural biology, proteomics, and cell biology colleagues to detect, visualise, and interrogate ubiquitin signalling.
• Shape toolkit applications, pursue biological questions, and create reusable research reagents.

Requirements

• Postdoctoral research background in protein biochemistry, molecular biology, or molecular recognition.
• Experience in protein biochemistry or molecular biology is required.
• Clear interest in ubiquitin signalling is required.
• Excellent experimental design, quantitative analysis, and problem-solving skills.
• Ability to work with minimal supervision.
• Rigorous and collaborative approach to research.

Nice to have

• Experience with protein engineering.
• Experience studying protein-protein interactions.
• Experience with cellular imaging.

Culture & Benefits

• Multidisciplinary and sociable research environment with biochemists, structural biologists, cell biologists, and proteomics researchers.
• Scientific ownership and mentoring tailored toward development and independence.
• Culture underpinned by inclusion, empathy, and integrity.
• Market-leading pension scheme and employee health and wellbeing services, including an Employee Assistance Programme.
• Annual leave, bank holidays, and additional paid closure over the Christmas period.
• Local and national retailer discounts.

Hiring process

• Upload a single PDF containing both your CV and cover letter.
• Applications close at midnight on the stated closing date.
• Applications and CVs from recruitment agencies are not accepted.