Manager, Quantitative Systems Pharmacology (mRNA)

Location: Melbourne, Australia; hybrid 70% in-office work model.

Company

hirify.global develops an mRNA technology platform and medicines intended to transform how treatments are created and delivered.

What you will do

• Develop and apply quantitative systems pharmacology models across hirify.global’s therapeutic portfolio and mRNA platform.
• Build mechanistic PK/PD, PBPK, and translational models to characterize drug disposition, pharmacological activity, dose, exposure, biomarkers, and clinical response.
• Apply modeling and simulation to candidate selection, preclinical-to-clinical translation, first-in-human dose selection, dose escalation, and dose-regimen optimization.
• Integrate in vitro, in vivo, clinical, and literature data; perform calibration, parameter estimation, sensitivity analysis, uncertainty analysis, and simulation.
• Collaborate with Pharmacology, Toxicology, Translational Medicine, Research, Clinical Development, and other cross-functional disciplines to support program decisions.
• Communicate modeling strategies, assumptions, results, and recommendations to multidisciplinary teams and scientific leadership; contribute to regulatory documents and interactions.

Requirements

• PhD in pharmaceutical sciences, biomedical engineering, chemical engineering, systems biology, computational biology, applied mathematics, or a related quantitative discipline.
• Experience developing and applying mechanistic mathematical models to biological or pharmacological systems.
• 1–4+ years of experience in quantitative pharmacology, including QSP, PK/PD, PBPK, or other mechanistic or differential equation-based modeling approaches supporting drug discovery and development.
• Strong knowledge of pharmacology, pharmacokinetics, drug development, and quantitative analysis.
• Experience integrating and analyzing preclinical and/or clinical pharmacology data for model development and simulation.
• Proficiency with quantitative modeling and scientific computing software such as MATLAB/SimBiology, R, Python, or similar platforms.
• Ability to independently formulate biological and pharmacological questions into quantitative modeling strategies.
• Strong scientific communication skills for explaining complex modeling concepts and results to quantitative and non-quantitative audiences.
• Demonstrated ability to collaborate effectively in multidisciplinary and cross-functional teams.

Culture & Benefits

• In-person collaboration supported by a 70/30 work model, with significant office-based work and direct mentorship.
• Healthcare and voluntary benefit programs, with offerings varying by employment type and country.
• Fitness, mindfulness, and mental health resources.
• Family-building support, including fertility, adoption, and surrogacy benefits.
• Paid time off including vacation, bank holidays, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown.
• Savings and investment programs, plus location-specific perks.