19 дней назад
Associate Manager, Statistical Genetics (Genetics)
Мэтч & Сопровод
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Описание вакансии
Текст:
TL;DR
Associate Manager, Statistical Genetics (Genetics): Building and maintaining high-throughput tools and workflows for genome-scale analyses of genetic and phenotype data from millions of individuals with an accent on genome-wide association studies, rare variant analysis, and quality control. Focus on managing cloud-based genomic analysis systems, troubleshooting analyses at scale, and interpreting results across cardiovascular, metabolic, and skeletal diseases.
Location: Tarrytown, New York, United States; 4 days onsite
Company
is a biotechnology company that develops medicines for serious diseases using genetics, health data, and translational science.
What you will do
- Perform genome-scale analyses using genotype, imputed, and sequence data from millions of individuals across phenotypes and biomarkers.
- Build, maintain, and improve analytical workflows that follow genomic analysis best practices.
- Build and manage high-throughput systems for genomic analysis execution, tracking, and post-analysis quality control.
- Test and integrate computational tools across quantitative, health outcome, and molecular datasets.
- Review analysis plans, results, and summaries for accuracy and reliability while identifying problems and proposing analytical refinements.
- Collaborate with specialists in genomic data analysis, translational genetics, functional biology, and medicine on cardiovascular, metabolic, and skeletal diseases.
Requirements
- PhD in Human Genetics, Biostatistics, or a related field.
- 0–2 years of experience; postdoctoral training or relevant industry experience is preferred.
- Experience with genome- and exome-wide association analysis, rare variant analysis, Mendelian randomization, LD Score regression, polygenic risk score modeling, meta-analysis, and functional data for variant and gene prioritization.
- Experience analyzing large genetic association studies and biobank-scale data, including UK Biobank or comparable datasets.
- Familiarity with genetic and phenotype data management, VCF files, genotype imputation, and quality control of genetic association inputs and outputs.
- Expertise with cloud computing and tools such as PLINK and REGENIE; statistical programming in R, Python, and C/C++ is necessary.
Nice to have
- Experience working with cardiovascular, metabolic, or musculoskeletal diseases.
Culture & Benefits
- Inclusive workplace and equal opportunity employment.
- Comprehensive rewards package that may include bonuses, equity awards, retirement benefits, health and wellness programs, insurance, paid time off, and family support benefits.
- Reasonable accommodations are available during recruitment for applicants with disabilities or chronic illnesses where required.
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