2 дня назад
Scientific Associate Director - Safety Pharmacology (Biotech)
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Описание вакансии
Текст:
TL;DR
Scientific Associate Director - Safety Pharmacology (Biotech): Leading cardiac safety and electrophysiology laboratory activities, GLP-compliant studies, and safety pharmacology strategy across small molecules, biologics, and emerging therapeutic modalities with an accent on in vitro cardiac assays, data integration, and clinical translation. Focus on managing scientific staff, interpreting target- and off-target safety risks, guiding regulatory strategy, and advancing human-relevant NAMs and modality-specific safety practices.
Location: Thousand Oaks, California, United States
Company
is a biotechnology company developing and delivering medicines for serious illnesses across oncology, inflammation, general medicine, and rare disease.
What you will do
- Lead the cardiac safety and electrophysiology laboratory, including ion channel, hiPSC-derived cardiomyocyte, and isolated heart assays.
- Manage exploratory and GLP-compliant studies, including protocol development, outsourcing, data review, reporting, and study tracking.
- Supervise and develop scientific staff while ensuring high-quality, timely data generation and compliance with data integrity, safety, and environmental standards.
- Serve as a Safety Pharmacology Subject Matter Expert on translational safety and risk sciences project teams.
- Guide safety strategy, study design, data interpretation, and recommendations for lead optimization, candidate selection, clinical translation, and regulatory submissions.
- Coordinate investigative studies and collaborations with internal teams, contract research organizations, academic partners, industry groups, and consortia.
Requirements
- Doctorate degree with 4 years of relevant scientific experience, or a master’s degree with 7 years, or a bachelor’s degree with 9 years.
- Experience in safety pharmacology, cardiac safety, electrophysiology, and laboratory-based assay systems.
- Ability to integrate in vitro and in silico data across drug modalities, including small molecules, biologics, oligonucleotides, and other emerging therapeutics.
- Knowledge of evolving ICH safety pharmacology guidelines, including S7A and S7B/E14.
- Work location: Thousand Oaks, California, United States.
Culture & Benefits
- Comprehensive medical, dental, vision, life, disability, and flexible spending benefits.
- Retirement and savings plan with company contributions.
- Annual discretionary bonus program and stock-based long-term incentives.
- Award-winning paid time-off plans.
- Flexible work models where applicable to the stated work location type.
- Opportunities to publish research, present at scientific events, and contribute to industry best practices.
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