Scientist – Lentiviral Vector Downstream Process Development

Location: Spring House, Pennsylvania, United States of America; full-time onsite role. Up to 10% domestic and international travel may be required, with occasional weekend work.

Company

Johnson & Johnson MedTech develops healthcare solutions across Innovative Medicine and MedTech to prevent, treat, and cure complex diseases.

What you will do

• Design, execute, optimize, and characterize downstream process development studies for lentiviral therapeutic products.
• Conduct purification experiments using chromatography, clarification, depth filtration, sterile filtration, UF/DF, formulation, and automated high-throughput systems.
• Operate and manage downstream equipment, including AKTA systems, TFF systems, and purification skids.
• Improve productivity, product quality, manufacturability, process robustness, and development efficiency across lentiviral processes.
• Support technology transfer, commercial manufacturing investigations, and product lifecycle management as a downstream subject matter expert.
• Collaborate with upstream, analytical, formulation, modeling, and automation functions; prepare technical reports, protocols, presentations, and regulatory-supporting documentation.

Requirements

• BS or MS in Chemical Engineering, Biochemical Engineering, Biological Sciences, Biotechnology, or a related field, plus 2–4 years of relevant industry experience, or experience developing processes for viral-based products.
• Experience with purification process development for biologics, cell and gene therapy, RNA therapeutics, or related viral vector modalities.
• Hands-on experience with chromatography, clarification, depth filtration, UF/DF, sterile filtration, and process scale-up.
• Strong data analysis, statistical experimental design, technical documentation, written communication, and verbal communication skills.
• Ability to work effectively in cross-functional team environments.
• Experience with JMP, MiniTab, Python, Spotfire, or similar platforms for process data analysis and visualization.

Nice to have

• Previous technology transfer experience involving clinical or commercial GMP bioprocess manufacturing.
• Knowledge of emerging downstream technologies that improve process robustness and development efficiency.

Culture & Benefits

• Inclusive work environment guided by Johnson & Johnson’s Credo.
• Opportunity to contribute to cell therapy and CAR-T programs across early, clinical, and commercial development stages.
• Equal opportunity employment and an inclusive interview process with accommodation support for applicants with disabilities.