21 час назад
Scientist (Hematopoietic Stem Cell, Genome Editing)
86 320 - 154 960$
Вакансия из Hirify Global, списка международных tech-компанийДля мэтча и отклика нужен Plus
Мэтч & Сопровод
Для мэтча с этой вакансией нужен Plus
Описание вакансии
Текст:
TL;DR
Scientist (Hematopoietic Stem Cell, Genome Editing): Developing genome editing strategies and IND-enabling studies for human hematopoietic stem cell products targeting sickle cell disease, with an accent on cellular therapy, safety and potency characterization, and process development. Focus on optimizing in-vitro and in-vivo delivery strategies, analyzing on-target and off-target editing through sequencing, and transferring reproducible processes to GMP manufacturing.
Location: Memphis, Tennessee, United States; this position is based in Memphis and relocation assistance is available.
Salary: $86,320–$154,960 per year
Company
advances research and treatment for pediatric cancer and other catastrophic diseases.
What you will do
- Develop genome editing strategies for human hematopoietic stem cells to support sickle cell disease therapies.
- Design and execute IND-enabling pharmacology, safety, efficacy, and potency studies for genome-edited cellular products.
- Perform multicolor flow cytometry, FACS sorting, in-vitro assays, and xenotransplantation studies.
- Develop RT-PCR, ddPCR, next-generation sequencing, and single-cell sequencing methods, including library preparation and editing-outcome analysis.
- Evaluate scale-up and closed-system processes, track pilot runs, and improve product reproducibility.
- Collaborate with multidisciplinary research teams and prepare protocols, batch records, and reports for GMP process transfer.
Requirements
- Bachelor’s degree in a relevant scientific field.
- Relevant post-degree experience: 8 years with a bachelor’s degree, 6 years with a master’s degree, or 3 years with a PhD.
- Expertise in hematopoietic stem cell biology and genome editing technologies.
- Experience leading and supporting research experiments.
- Regular and predictable attendance is required.
Nice to have
- Master’s or PhD degree in a relevant scientific field.
- Experience coordinating laboratory and scientific projects.
- Experience guiding and training laboratory personnel.
Culture & Benefits
- Work with an interdisciplinary team of scientists and clinical researchers.
- Contribute to a genome editing program advancing toward a Phase 1 clinical trial.
- Relocation assistance is available for the Memphis-based position.
- Benefits are available through St. Jude Children’s Research Hospital.
Hiring process
- A cover letter is highly recommended and should be addressed to Jonathan Yen, PhD.
- Applicants should submit a cover letter as part of the application process.
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