Senior Scientist, Multiomics Discovery

Location: Spring House, Pennsylvania, United States of America

Company

Johnson & Johnson MedTech develops healthcare and medical solutions across Innovative Medicine and MedTech.

What you will do

• Design, construct, and optimize genetic libraries for CRISPR perturbation, reporter assays, overexpression systems, and multiplexed functional studies.
• Develop complex phenotypic assays, including FACS-based workflows, high-content imaging, pooled optical screens, and massively parallel reporter assays.
• Engineer and characterize primary and advanced cellular models, including immune cells, iPSCs, organoids, co-culture systems, and 3D cellular architectures.
• Implement pooled and arrayed screening platforms and optimize perturbation library delivery, expression, and representation.
• Collaborate with computational scientists on experimental metadata, data quality, interpretation, and basic computational analysis.
• Drive assay innovation, document and present findings, support strategic project planning, and develop expertise in spatial omics and related genomics areas.

Requirements

• PhD in genetics, genomics, molecular biology, cell biology, systems biology, human biology, or a related discipline.
• Post-doctoral fellowship in a related field, or industry experience delivering completed complex projects.
• At least 3 years of biotech or pharmaceutical industry experience, or post-doctoral/academic staff scientist experience in a deeply technical role.
• Deep technical expertise in massively parallel cell perturbation using genetic tools, including end-to-end workflows, limitations, and mitigation strategies.
• Experience with complex models, genetic screens, cross-disciplinary collaboration, and high-impact scientific deliverables.
• Excellent written, verbal, and presentation skills.

Nice to have

• Proficiency in R or Python.
• Experience with spatial omics, in vivo screens, histology, pathology, or NGS.

Culture & Benefits

• Inclusive work environment grounded in individual respect, diversity, and dignity.
• Opportunity to contribute to healthcare innovation and develop treatments for complex diseases.
• Cross-functional collaboration with multidisciplinary scientific and computational teams.
• Interview accommodations are available for applicants with disabilities.