Postdoctoral Research Fellow — Clonal Evolution and Genome Engineering in Inherited Bone Marrow Failure Disorders

Location: Memphis, TN, United States

Salary: Starting at $72,500 per year

Company

hirify.global is a pediatric research institution focused on cancer and other catastrophic diseases of childhood, with a multidisciplinary biomedical research environment.

What you will do

• Study clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, especially Shwachman-Diamond syndrome.
• Investigate how somatic adaptation shapes disease trajectory and distinguishes compensatory from pre-malignant clones.
• Develop and analyze primary patient samples and iPSC cell line models.
• Conduct CRISPR and base-editing screens and evaluate therapeutic genome-editing strategies.
• Apply single-cell genomics and quantitative analysis to research questions.
• Work with a clinical bone marrow failure program in a collaborative research environment.

Requirements

• PhD, MD, or MD/PhD in hematology, cancer biology, genetics, genome engineering, immunology, or a related field, completed or expected within six months.
• At least one first-author publication, published or in press.
• Hands-on experience with mammalian cell culture, cloning, qPCR, flow cytometry, Western blot, single-cell RNA sequencing, and basic biochemistry.
• Quantitative data analysis skills and clear scientific writing.
• Ability to work independently and collaboratively.

Nice to have

• CRISPR/Cas9 or base/prime editing experience, including guide design and editing outcome analysis.
• Primary hematopoietic stem and progenitor cell culture, CD34+ work, or xenotransplantation and murine model experience.
• NGS analysis experience with scRNA-seq, targeted error-corrected sequencing, WES, or WGS.
• Fluency in R or Python.

Culture & Benefits

• Access to shared research resources, expert scientists, and advanced technologies.
• Professional development programs, grant-writing workshops, individual development plans, and teaching and mentoring opportunities.
• Non-research career development programs and a professional development allowance.
• Comprehensive benefits and generous relocation assistance.
• Supportive postdoctoral community and a collaborative multidisciplinary environment.